Case Study 1:Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following:Atenolol 12.5 mg dailyDoxazosin 8 mg dailyHydralazine 10 mg qidSertraline 25 mg dailySimvastatin 80 mg dailyCase Study 2:Patient HM has a history of atrial fibrillation and a transient ischemic attack (TIA). The patient has been diagnosed with type 2 diabetes, hypertension, hyperlipidemia and ischemic heart disease. Drugs currently prescribed include the following:Warfarin 5 mg daily MWF and 2.5 mg daily T, TH, Sat, SunAspirin 81 mg dailyMetformin 1000 mg po bidGlyburide 10 mg bidAtenolol 100 mg po dailyMotrin 200 mg 1–3 tablets every 6 hours as needed for painCase Study 3:Patient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following:Glipizide 10 mg po dailyHCTZ 25 mg dailyAtenolol 25 mg po dailyHydralazine 25 mg qidSimvastatin 80 mg dailyVerapamil 180 mg CD dailyTo prepare:Review this week’s media presentation on hypertension and hyperlipidemia, as well as Chapters 19 and 20 of the Arcangelo and Peterson text.Select one of the three case studies, as well as one the following factors: genetics, gender, ethnicity, age, or behavior factors.Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.With these thoughts in mind:By Day 3Post an explanation of how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you selected. Then, describe how changes in the processes might impact the patient’s recommended drug therapy. Finally, explain how you might improve the patient’s drug therapy plan.
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