Explain the differences between the four main actions a drug can have after binding to a receptor. Describe what an agonist, partial agonist, antagonist, and inverse agonist are. List one or two psychiatric medications that are an example of each of these categories

Explain the differences between the four main actions a drug can have after binding to a receptor. Describe what an agonist, partial agonist, antagonist, and inverse agonist are. List one or two psychiatric medications that are an example of each of these categories.

Directions

Address the following in a paper no longer than two double-spaced pages (not including the reference page) and in APA format. Include at least three peer-reviewed, evidence-based references.

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1. Explain the differences between the four main actions a drug can have after binding to a receptor. Describe what an agonist, partial agonist, antagonist, and inverse agonist are. List one or two psychiatric medications that are an example of each of these categories.

2. What is a G-protein-linked receptor? What is an ion channel? How do these differ from each other? Give an example of a neurotransmitter and a medication that act on a G-protein receptor and ion channel.

3. Explain how this information influences how you prescribe medications. Give an example of a patient case or scenario where understanding the drug’s action at the receptor would be critically important in safely treating the patient.

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Rubric

G-Protein-Linked Receptors

G-Protein-Linked Receptors
Criteria Ratings Pts
This criterion is linked to a Learning OutcomeAgonist-to-Antagonist Spectrum and Medications
10.0 to >8.0 pts

All information is accurate and shows a deep understanding of the spectrum. Includes 2 medications in each category.

 8.0 to >6.0 pts

Most information is accurate and shows a strong understanding of the spectrum. Includes 1 or 2 medications in each category.

 6.0 to >4.0 pts

Some information is accurate and shows a basic understanding of the spectrum. Includes 1 or 2 medications in each category.

 4.0 to >2.0 pts

Most information is inaccurate and shows little understanding of the spectrum. Includes 0-1 medications in each category.

 2.0 to >0 pts

Information is inaccurate and shows no effort in understanding the spectrum. Does not includes medications in each category.

 

 10.0 pts
This criterion is linked to a Learning OutcomeReceptor Superfamilies
10.0 to >8.0 pts

All information is accurate and shows a deep understanding of the receptor superfamilies.

 8.0 to >6.0 pts

Most information is accurate and shows a strong understanding the receptor superfamilies.

 6.0 to >4.0 pts

Some information is accurate and shows a basic understanding of the receptor superfamilies.

 4.0 to >2.0 pts

Most information is inaccurate and shows little understanding the receptor superfamilies.

 2.0 to >0 pts

Information is inaccurate and shows no effort in understanding the receptor superfamilies.

 

 10.0 pts
This criterion is linked to a Learning OutcomeImpact
10.0 to >8.0 pts

All information is accurate and shows a deep understanding of the impact on prescribing. Includes a well-written, appropriate example.

 8.0 to >6.0 pts

Most information is accurate and shows a strong understanding of the impact on prescribing. Includes an appropriate example.

 6.0 to >4.0 pts

Some information is accurate and shows a basic understanding of the impact on prescribing. Includes a poorly written or not fully appropriate example.

 4.0 to >2.0 pts

Most information is inaccurate and shows little understanding of the impact on prescribing. Does not include an appropriate example.

 2.0 to >0 pts

Information is inaccurate and shows no effort in understanding the impact on prescribing. Does not include an appropriate example.

 

 10.0 pts
This criterion is linked to a Learning OutcomeWriting, Composition, Grammar, Spelling, References, and APA Format
10.0 to >8.0 pts

Excellently written and composed. No errors in format, references, spelling, and grammar.

 8.0 to >6.0 pts

Well written and composed. A few minor errors in format, references, spelling, and/or grammar.

 6.0 to >4.0 pts

Somewhat well written and composed. Many minor errors in format, references, spelling, and/or grammar.

 4.0 to >2.0 pts

Poorly written and composed. Major errors in format, references, spelling, and/or grammar, but still understandable.

 2.0 to >0 pts

Very poorly written and composed. Major errors in format, references, spelling, and/or grammar make it difficult to understand.

 

 10.0 pts
Total Points: 40.0

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Explain the differences between the four main actions a drug can have after binding to a receptor. Describe what an agonist, partial agonist, antagonist, and inverse agonist are. List one or two psychiatric medications that are an example of each of these categories

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